Me and my genes on French radio!

Tomorrow I'm participating in a debate, on the French radio station France Culture, on the topic “Do genetic tests predict our future?”. The program’s name is Science Publique and it starts at 2 p.m. (Paris local time).

Tomorrow in Sciences et Avenir: my journey to my genes, revisited

My dear friend Dominique Leglu presents, in this video clip, the contents of the May issue of the magazine.

Luckily, I won't have to decide right away!

23andme anounced yesterday that is it now possible for their clients of European descent to know their Alzheimer's risk. This "diagnosis" includes the detection of a mutation, APOE ε4, known to substantially increase the risk of developping the disease.

Just as was the case with the hereditary breast cancer gene mutations when I received my first results, to see my results I would now have to click again on an opt-in button, signalling my informed consent.

I've long asked myself what I would do when the time came. Would I feel an irresistible urge to know? Being just a click away from the "truth" might turn out to be unbearable... And do I really want to know?

Now the time has come... but not exactly in my case, at least not immediately, because for that to happen I would have to get tested again, with a new kit. My current results are incomplete. I'm so relieved!

Cancer world

I learned today that my odds of having a squamous cell carcinoma - the second most common skin cancer, that usually develops on sun-exposed areas, namely on the face and hands - could be substantially higher than average. A study involving 537 persons afflicted by the disease and 1504 healthy controls, all of European descent, was published in Cancer Research , suggesting that a certain point mutation in a gene called IRF4 is associated with this cancer. And since I inherited the risky mutation from both my parents, my risk could be three times higher (2.89 to be exact). I know what I'm going to talk about with my dermatologist next time I see him.

True or April's false?

23andMe Discovers 24th Chromosome, Changes Name to 24andMe

Already 1,391

According to Relative Finder (RF) I have today 1,391 "genetic cousins" (Ashkenazi Jews like me have record numbers of cousins, probably owing to their over-representation as 23andme clients; for other possible explanations, see this previous post.)

I'm currently sharing my genetic information with 336 "cousins" and I've had 30 contact requests turned down (it happens). Also according to RF, I have a few dozen third cousins, a few fourth and fifth cousins, but the vast majority are so-called distant cousins - that is, people with whom I might share an ancestor from several centuries ago. Up to now, I haven't been able to confirm any of the estimated closest relationships, something I would have to do using the scarce information I have on my grand-parents, great-grandparents and so forth.

Oh cousin, who art thou?

23andme has a thing called Relative Finder which allows us to discover, among all the people who had their DNA analyzed by them, which are our "genetic cousins" - and also gives us the estimated proximity of that family relationship. But, for obvious privacy reasons, they don't reveal those persons' identities, and we are required to send them an invitation if we wish to contact them. Once we know who they are, we can proceed to try and compare paper trails and see if we have any known ancestors in common.

That's what I did with the one person estimated by RF to be my second cousin
(which would mean we have a set of great-grandparents in common): I sent her an invitation to contact me. She replied saying she accepted contact, but still didn't tell me who she was (did she forget to do it, did she not know how to do it, did she not wish to do it? I really don't know). But I still only know about her that she is a female and that her maternal haplogroup is N1b2. And I have no way to do anything else. I wrote her back several other messages, the last one on November 8, but still no answer. It's frustrating.